Umehluko phakathi kwe-α-arbutin ne-β-arbutin

i-α-arbutinkanye ne-β-arbutin yizinhlanganisela ezimbili zamakhemikhali ezihlobene eduze ezivame ukusetshenziswa emikhiqizweni yokunakekelwa kwesikhumba ngemiphumela yazo yokukhanyisa nokukhanyisa isikhumba. Nakuba zabelana ngesakhiwo esiyinhloko esifanayo kanye nendlela yokusebenza, kukhona umehluko omncane phakathi kwalezi ezimbili ongathinta ukusebenza kwazo kanye nemiphumela emibi engaba khona.

Ngokwesakhiwo, i-α-arbutin kanye ne-β-arbutin ziyi-glycosides ye-hydroquinone, okusho ukuthi zine-molecule ye-glucose exhunywe kwi-molecule ye-hydroquinone. Lokhu kufana kwesakhiwo kuvumela zombili izinhlanganisela ukuthi zivimbele i-enzyme i-tyrosinase, ehilelekile ekukhiqizweni kwe-melanin. Ngokuvimbela i-tyrosinase, lezi zinhlanganisela zingasiza ekunciphiseni ukukhiqizwa kwe-melanin, okuholela esikhumbeni esikhanyayo nesilinganayo.

Umehluko omkhulu phakathi kwe-α-arbutin ne-β-arbutin usesikhundleni sesibopho se-glycosidic phakathi kwezingxenye ze-glucose ne-hydroquinone:

I-α-arbutin: Ku-α-arbutin, isibopho se-glycosidic sinamathele endaweni ye-alpha yendandatho ye-hydroquinone. Lokhu kubekwa kukholakala ukuthi kuthuthukisa ukuzinza nokuncibilika kwe-α-arbutin, okwenza kube ngcono kakhulu ekusetshenzisweni kwesikhumba. Isibopho se-glycosidic siphinde sinciphise amandla okushiswa kwe-hydroquinone, okungaholela ekwakhekeni kwamakhemikhali amnyama aphikisana nomphumela ofiselekayo wokukhanyisa isikhumba.

I-β-arbutin: Ku-β-arbutin, isibopho se-glycosidic sinamathele endaweni ye-beta yendandatho ye-hydroquinone. Nakuba i-β-arbutin nayo isebenza kahle ekuvimbeleni i-tyrosinase, ingase ingazinzile njenge-α-arbutin futhi ithambekele kakhulu ekufakweni kwe-oxidation. Lokhu kufakwe kwe-oxidation kungabangela ukwakheka kwamakhemikhali ansundu angafiseleki kangako ekukhanyeni kwesikhumba.

Ngenxa yokuzinza kwayo okukhulu kanye nokuncibilika kwayo, i-α-arbutin ivame ukubhekwa njengendlela ephumelela kakhulu futhi ekhethwayo yokusetshenziswa kokunakekelwa kwesikhumba. Kukholakala ukuthi iletha imiphumela engcono yokukhanyisa isikhumba futhi cishe ayinakho ukubangela ukushintsha kombala noma imiphumela emibi engafuneki.

Uma ucabangela imikhiqizo yokunakekela isikhumba equkethei-arbutin, kubalulekile ukufunda ilebula lezithako ukuze kutholakale ukuthi i-α-arbutin noma i-β-arbutin iyasetshenziswa yini. Nakuba zombili lezi zinhlanganisela zingasebenza kahle, i-α-arbutin ngokuvamile ibhekwa njengokukhetha okuhle kakhulu ngenxa yokuqina kwayo okuthuthukisiwe kanye namandla ayo.

Kubalulekile futhi ukuqaphela ukuthi ukuzwela kwesikhumba komuntu ngamunye kungahluka. Abanye abantu bangase babe nemiphumela emibi njengokucasuka kwesikhumba noma ukubomvu lapho besebenzisa imikhiqizo equkethe i-arbutin. Njenganoma yisiphi isithako sokunakekelwa kwesikhumba, kunconywa ukuthi wenze isivivinyo se-patch ngaphambi kokufaka umkhiqizo endaweni enkulu yesikhumba futhi uthintane nodokotela wesikhumba uma unenkinga mayelana nokusabela okungenzeka.

Ekuphetheni, kokubili i-α-arbutin kanye ne-β-arbutin ziyi-glycosides ye-hydroquinone esetshenziselwa imiphumela yazo yokukhanyisa isikhumba. Kodwa-ke, ukubeka kwe-α-arbutin isibopho se-glycosidic endaweni ye-alpha kuyinika ukuzinza okukhulu kanye nokuncibilika, okwenza kube ukukhetha okuthandwa kakhulu kwemikhiqizo yokunakekelwa kwesikhumba okuhlose ukunciphisa i-hyperpigmentation nokufeza ithoni yesikhumba elinganayo.