I-formaldehyde ne-glutaraldehydeBobabili abahlinzeki bamakhemikhali basebenzise njenge-Crosslinking Agents kuzicelo ezahlukahlukene, ikakhulukazi emikhakheni ye-biology, chemistry, kanye nesayensi yezinto zokwakha. Ngenkathi zisebenzela izinjongo ezifanayo ekunqandeni ama-biomolekces futhi kulondolozwa ama-specials asezingeni eliphakeme, anezinto ezihlukile zamakhemikhali, ukusebenziseka, ubuthi kanye nezicelo.
Ukufana:
Ama-ejenti wokuwela: zombili i-formaldehyde futhiI-Glutaraldehyde yi-Aldehydes, okusho ukuthi baneqembu le-carbonyl (-cho) ekugcineni kwesakhiwo sabo se-molecular. Umsebenzi wabo oyinhloko ukwakha izibopho ezi-combared phakathi kwamaqembu asebenzayo we-biomolecule, okuholele ekuweni. Ukuwela kubalulekile ekuqiniseni ukwakheka kwamasampula endalo, kubenza baba namandla ngokwengeziwe futhi bamelane nokonakaliswa.
Izicelo ze-Biomedical: Womabili ama-formaldehyde ne-glutaraldehyde thola ukusetshenziswa okubalulekile emkhakheni we-biomedical. Bajwayele ukuqashwa ngenxa yezicubu kanye nokulondolozwa kwe-Histology kanye nama-Pathology Study. Izicubu ezinqamule zigcina ubuqotho babo besakhiwo futhi zingaphinde zicutshungulwe ngezinjongo ezahlukahlukene zokuhlaziya nokuxilonga.
Ukulawulwa kwe-Microbial: Womabili la ma-ejenti anezakhiwo ze-antimicrobial, abenze babalulekelweni lokubulala amagciwane kanye nezinqubo zokunyusa inzalo. Bangakwazi ukwenza i-bacteria, amagciwane, kanye nesikhunta, behlisa ubungozi bokungcoliswa kwezilungiselelo zelebhu kanye nemishini yezokwelapha.
Izicelo zezimboni: zombili i-formaldehyde futhiglutaraldehydezisetshenziselwa izinhlelo ezahlukahlukene zezimboni. Baqashwa ekukhiqizeni izinamathela, ama-resin kanye nama-polymers, kanye nasezimbonini zesikhumba kanye nezindwangu.
Umehluko:
Isakhiwo samakhemikhali: Umehluko oyinhloko phakathi kwe-formaldehyde ne-glutaraldehyde ilele ezinhlakeni zazo ze-molecular. I-OrganDehyde (CH2O) iyi-aldehyde elula kunazo zonke, eyakhiwa i-athomu elilodwa lekhabhoni, ama-athomu amabili e-hydrogen, ne-athomu elilodwa le-oxygen. I-Glutaraldehyde (C5h8o2), ngakolunye uhlangothi, iyinto eyinkimbinkimbi yama-aldehyde, equkethe ama-athomu ama-athomu amahlanu, ama-athomu ayisishiyagalombili ama-athomu, nama-athomu amabili oksijini.
Ukusebenza kabusha: Ngokuvamile i-Gutaraldehyde isebenza kakhulu kune-formaldehyde ngenxa ye-carbon chain yayo ende. Ukuba khona kwama-athomu ama-athomu amahlanu e-Glutaraldehyde kuyakuvumela ukuba kubhulokwe amabanga amade phakathi kwamaqembu asebenzayo kuma-biomolecule, okuholela ekunciphiseni okusheshayo nokusebenza kahle.
Ukusebenza kahle kwe-Crossinking I-formaldehyde, ngenkathi isakwazi ukuwela, kungadinga isikhathi esithe xaxa noma ukugxila okuphezulu ukufeza imiphumela eqhathaniswa nama-molecule amakhulu.
Ubuthi: I-Glutaraldehyde yaziwa njengenobuthi kakhudlwana kune-formaldehyde. Ukuchayeka isikhathi eside noma okubalulekile ku-Glutaraldehyde kungadala ukucasuka kwesikhumba nokuphefumula, futhi kubhekwa njenge-sensitizer, okusho ukuthi kungaholela ekuvumeleni komzimba komunye nabantu. Ngokuphambene, i-formaldehyde iyi-carcinogen eyaziwayo futhi ibeka ubungozi bezempilo, ikakhulukazi lapho i-inhalid noma ukuxhumana nesikhumba.
Izicelo: Yize womabili womabili amakhemikhali asetshenziswa ekuhlelweni kwezicubu, ajwayele ukuthandwa ngezinhloso ezihlukile. I-formaldehyde imvamisa isetshenziselwa izinhlelo zomlando ezijwayelekile kanye nokugqumisa, ngenkathi i-Glutaraldehyde ilungele ukwakhiwa kwezinhlaka zamaselula nezindawo ze-antigenic kwizifundo ze-lembron microscopy kanye ne-immunocistochemical Study.
Ukuqina: I-Formalicyde iguquguqukayo futhi ivame ukuhwamuka ngokushesha kune-Glutaraldehyde. Le mpahla ingathonya izidingo zokuphatha nokugcina ama-crosslinking agents.
Ngamafuphi, i-formaldehyde kanye ne-glutaraldehyde yabelana ngezici ezijwayelekile njengabameli be-crosslinking, kepha bahluke kakhulu ezinhlakeni zabo zamakhemikhali, ukusebenziseka, ubuthi kanye nezicelo. Ukuqonda okufanele ngalo mehluko kubalulekile ekukhetheni i-ejenti efanelekile yezinhloso ezithile kanye nokuqinisekisa ukusetshenziswa okuphephile nangokuphumelelayo ezindaweni ezahlukahlukene zesayensi, zezokwelapha, nezimboni.
Isikhathi sePosi: Jul-28-2023