I-Formaldehyde kanye ne-glutaraldehydeZombili lezi zinto ziyizinto zamakhemikhali ezisetshenziswa njengezinto zokuxhumanisa ezisetshenziswayo ezahlukahlukene, ikakhulukazi emikhakheni yebhayoloji, ikhemistri, kanye nesayensi yezinto ezibonakalayo. Nakuba zifeza izinjongo ezifanayo ekuhlanganiseni izinto eziphilayo kanye nokugcina amasampula ezinto eziphilayo, zinezakhiwo zamakhemikhali ezihlukile, ukusabela, ubuthi, kanye nezinhlelo zokusebenza.
Ukufana:
Ama-Crosslinking Agents: Kokubili i-formaldehyde kanyei-glutaraldehyde yi-aldehydes, okusho ukuthi baneqembu le-carbonyl (-CHO) ekugcineni kwesakhiwo sabo sama-molecule. Umsebenzi wabo oyinhloko ukwakha izibopho ezihambisanayo phakathi kwamaqembu asebenzayo ama-biomolecule, okuholela ekuxhumeni. Ukuxhumanisa kubalulekile ekuqiniseni isakhiwo samasampula ezinto eziphilayo, okwenza aqine futhi amelane nokuwohloka.
Ukusetshenziswa Kwezokwelapha: Kokubili i-formaldehyde ne-glutaraldehyde kusetshenziswa kakhulu emkhakheni wezokwelapha. Zivame ukusetshenziswa ekuqiniseni nasekulondolozeni izicubu ezifundweni ze-histology kanye ne-pathology. Izicubu ezixhumene zigcina ubuqotho bazo besakhiwo futhi zingacutshungulwa kabanzi ngezinjongo ezahlukahlukene zokuhlaziya nokuxilonga.
Ukulawulwa Kwamagciwane: Zombili lezi zinto zinezakhiwo zokulwa namagciwane, okwenza zibe usizo ezinqubweni zokubulala amagciwane kanye nokubulala amagciwane. Zingavala amagciwane, amagciwane kanye nesikhunta, zinciphise ingozi yokungcola ezindaweni zelebhu kanye nemishini yezokwelapha.
Izicelo Zezimboni: Kokubili i-formaldehyde kanyei-glutaraldehydeZisetshenziswa ezimbonini ezahlukahlukene. Zisetshenziswa ekukhiqizeni izinti zokunamathisela, ama-resin, nama-polymer, kanye nasezimbonini zesikhumba nezendwangu.
Umehluko:
Isakhiwo Samakhemikhali: Umehluko omkhulu phakathi kwe-formaldehyde ne-glutaraldehyde usezakhiweni zawo zama-molecule. I-Formaldehyde (CH2O) iyi-aldehyde elula kakhulu, eyakhiwe yi-athomu eyodwa yekhabhoni, ama-athomu amabili e-hydrogen, kanye ne-athomu eyodwa ye-oxygen. I-Glutaraldehyde (C5H8O2), ngakolunye uhlangothi, iyi-aldehyde eyinkimbinkimbi kakhulu ye-aliphatic, equkethe ama-athomu amahlanu ekhabhoni, ama-athomu ayisishiyagalombili e-hydrogen, kanye nama-athomu amabili e-oxygen.
Ukusabela: I-Glutaraldehyde ngokuvamile isabela kakhulu kune-formaldehyde ngenxa yochungechunge lwayo lwekhabhoni olude. Ukuba khona kwama-athomu amahlanu ekhabhoni ku-glutaraldehyde kuyivumela ukuthi ihlanganise amabanga amade phakathi kwamaqembu asebenzayo kuma-biomolecule, okuholela ekuxhumeni okusheshayo nokuphumelelayo.
Ukusebenza Kahle Kokuxhumanisa: Ngenxa yokusabela kwayo okuphezulu, i-glutaraldehyde ivame ukusebenza kangcono ekuxhumeni ama-biomolecule amakhulu, njengeprotheni nama-enzyme. I-Formaldehyde, yize isakwazi ukuxhumanisa, ingadinga isikhathi esengeziwe noma amazinga aphezulu ukuze kufezwe imiphumela efanayo nama-molecule amakhulu.
Ubuthi: I-Glutaraldehyde yaziwa ukuthi inobuthi kakhulu kune-formaldehyde. Ukuchayeka isikhathi eside noma okukhulu ku-glutaraldehyde kungabangela ukucasuka kwesikhumba nokuphefumula, futhi kubhekwa njengento ezwelayo, okusho ukuthi ingaholela ekuguleni kwabanye abantu. Ngokuphambene nalokho, i-formaldehyde iyingozi kakhulu emzimbeni futhi ibeka engcupheni impilo, ikakhulukazi uma iphefumulelwe noma ithinta isikhumba.
Ukusetshenziswa: Nakuba womabili amakhemikhali esetshenziswa ekuqiniseni izicubu, avame ukuthandwa ngezinjongo ezahlukene. I-Formaldehyde ivame ukusetshenziswa ekusetshenzisweni okuvamile kwe-histological kanye nokugqumisa, kuyilapho i-glutaraldehyde ifaneleka kakhulu ekulondolozeni izakhiwo zamaseli kanye nezindawo ze-antigenic ezifundweni ze-electron microscopy kanye ne-immunohistochemical.
Ukuzinza: I-Formaldehyde iyashintshashintsha kakhulu futhi ivame ukuhwamuka ngokushesha kune-glutaraldehyde. Lesi sici singathinta izidingo zokuphatha nokugcina zama-agent axhumanisayo.
Ngamafuphi, i-formaldehyde ne-glutaraldehyde zabelana ngezici ezifanayo njengezinto ezihlanganisayo, kodwa zihluka kakhulu ngezakhiwo zazo zamakhemikhali, ukusabela kwazo, ubuthi, kanye nokusetshenziswa kwazo. Ukuqonda kahle lokhu mehluko kubalulekile ekukhetheni i-ejenti ehlanganisayo efanele ngezinjongo ezithile kanye nokuqinisekisa ukusetshenziswa okuphephile nokusebenzayo ezimweni ezahlukene zesayensi, zezokwelapha, kanye nezezimboni.
Isikhathi sokuthunyelwe: Julayi-28-2023