I-Arbutiniyinhlanganisela yemvelo etholakala emithonjeni eyahlukene yezitshalo njenge-bearberry, i-cranberries, nama-blueberries. Ithole ukunakwa okukhulu embonini yokunakekelwa kwesikhumba kanye nezimonyo ngenxa yezakhiwo zayo zokwenza isikhumba sibe mhlophe futhi sikhanye. Indlela esebenza ngayo imiphumela yokwenza mhlophe igxile emandleni ayo okuvimbela umsebenzi we-enzyme ebizwa ngokuthi i-tyrosinase, edlala indima ebalulekile ekukhiqizweni kwe-melanin - umbala obangela isikhumba, izinwele, nombala wamehlo.
Umbala wesikhumba unqunywa inani kanye nokusatshalaliswa kwe-melanin ekhiqizwa yi-melanocytes, amaseli akhethekile kungqimba lwe-epidermal. I-Tyrosinase iyi-enzyme ebalulekile endleleni yokwenziwa kwe-melanin, ekhuthaza ukuguqulwa kwe-amino acid tyrosine ibe yi-melanin precursors, okugcina kuholele ekwakhekeni kwe-melanin pigments. I-Arbutin isebenzisa umphumela wayo wokuba mhlophe ngokuyinhloko ngokuvimbela umsebenzi we-tyrosinase ngokuncintisana.
I-Arbutin iqukethe isibopho se-glycoside, okuwukuxhumana kwamakhemikhali phakathi kwe-molecule ye-glucose ne-molecule ye-hydroquinone. I-Hydroquinone iyinhlanganisela eyaziwayo enezakhiwo zokukhanyisa isikhumba, kodwa ingaba nzima esikhumbeni futhi ihlotshaniswa nemiphumela emibi engaba khona. I-Arbutin, ngakolunye uhlangothi, isebenza njengendlela ehlukile ethambile kune-hydroquinone ngenkathi isanikeza ukuvimbela okusebenzayo kokukhiqizwa kwe-melanin.
Uma i-arbutin isetshenziswa esikhumbeni, iyamuncwa futhi ixutshwe ibe yi-hydroquinone ngezinqubo ze-enzyme. Le hydroquinone ibe isivimbela ngokuncintisana isenzo se-tyrosinase ngokuthatha indawo yayo esebenzayo. Ngenxa yalokho, ama-molecule e-tyrosine awakwazi ukuguqulwa ngempumelelo abe ama-melanin precursors, okuholela ekunciphiseni ukukhiqizwa kwe-melanin. Lokhu ekugcineni kuphumela ekunciphiseni kancane kancane kombala wesikhumba, okuholela esikhumbeni esikhanyayo nesilinganayo.
Kubalulekile ukuqaphela ukuthiukumhlophe kwe-arbutinimiphumela ayisheshi. Ukushintsha kwesikhumba kuthatha cishe inyanga, ngakho-ke ukusetshenziswa njalo nangokuqhubekayo kwemikhiqizo equkethe i-arbutin kuyadingeka ukuze kubonwe izinguquko ezibonakalayo ekushintsheni kombala wesikhumba. Ngaphezu kwalokho, indlela esebenza ngayo i-arbutin isebenza kangcono ekubhekaneni nezinkinga ezihlobene nokwanda kombala, njengezindawo zokuguga, izindawo zelanga, kanye ne-melasma, kunokushintsha umbala wesikhumba ongokwemvelo.
Iphrofayili yokuphepha ye-Arbutin ngokuvamile ibekezelelwa kangcono kunezinye izinto ezikhanyisa isikhumba, okwenza kube ukukhetha okuthandwayo kubantu abafuna ukubhekana nesikhumba esingalingani. Kodwa-ke, ukusabela komuntu ngamunye kungahluka, futhi kuyalulekwa ukwenza isivivinyo se-patch ngaphambi kokufaka imikhiqizo emisha yokunakekelwa kwesikhumba ohlelweni lwakho.
Ekuphetheni, indlela yokwenza isikhumba sibe mhlophe ye-arbutin incike emandleni ayo okuvimbela umsebenzi we-tyrosinase, okuholela ekunciphiseni ukukhiqizwa kwe-melanin. Ukuvimbela kwayo okuncintisanayo kwe-tyrosinase, okuholela ekunciphiseni ukwakheka kwe-melanin, kuyenza ibe yisithako esikhangayo emikhiqizweni yokunakekelwa kwesikhumba ehlose ukwakheka kwe-hyperpigmentation kanye nethoni yesikhumba engalingani. Njenganoma yisiphi isithako sokunakekelwa kwesikhumba, kunconywa ukuthi uthintane nodokotela wesikhumba ngaphambi kokwethula imikhiqizo emisha ohlelweni lwakho, ikakhulukazi uma unezinkinga noma izimo ezithile zesikhumba.
Isikhathi sokuthunyelwe: Agasti-30-2023