I-Pharmacodynamics ye-Chloroxylenol

I-Chloroxylenol, noma i-para-chloro-meta-xylenol (PCMX), iyi-ejenti eyaziwayo yokulwa namagciwane kanye nokubulala amagciwane. Iyi-ejenti yokuhlanza esetshenziswa ehholo lesibhedlela ukuhlanza amakhithi okuhlinza.

I-Chloroxylenol ingenye yezithako ezisebenzayo ezisetshenziswa ekwenzeni insipho yokubulala amagciwane. Futhi, ukusetshenziswa kwayo kuthinta kakhulu ezokwelapha kanye nasemakhaya njengesibulali-magciwane.

Ngokusho kohlu lwemithi ebalulekile ye-World Health Organization, ukuthambekela kwe-chloroxylenol ekulweni nohlobo lwebhaktheriya olwaziwa ngokuthi yi-Gram-positive, kubhalwe kahle.

Kodwa-ke, uma udinga umuthi omuhle wokulwa namagciwane kanye nokubulala amagciwane wezidingo zasekhaya kanye nezesibhedlela, kufanele uxhumane nochwepheshe othembekile.i-chloroxylenolumenzi.

Izinkomba ze-Chloroxylenol ze-Pharmacological

Ukusetshenziswa kwe-chloroxylenol kuvelele kakhulu emkhakheni wezokwelapha.

Ngaphambilini yayisetshenziswa ekwelapheni izifo zesikhumba ezifana nokuklwebheka, ukusikeka, ukulunywa yizilwane, ukuhlatshwa, kanye nesihlanzi sezandla.

I-Pharmacodynamics ye-Chloroxylenol

I-Chloroxylenoliyi-phenol ethatha indawo, okusho ukuthi ineqembu le-hydroxyl esakhiweni sayo.

Ukusetshenziswa kwayo kwaziwa kahle eminyakeni edlule njengenye yezingxenye ezisebenzayo zemikhiqizo yokubulala amagciwane. Ukusetshenziswa kwayo kuphakanyiswa ngaphandle kweseli.

Kubikwa ukuthi umsebenzi wayo wokulwa namagciwane ngenani elincane eqenjini lamagciwane.

Indlela Yokusebenza

Ukuba khona kwamaqembu e-hydroxyl esakhiweni sayo kubaluleke kakhulu, ikakhulukazi lapho kuzochazwa amandla ayo ezokwelapha.

Iqembu le-hydroxyl kucatshangwa ukuthi linamathela ezindaweni zokubopha zeprotheni, okusiza ekuvinjelweni kwebhaktheriya eliyihlaselayo.

I-Chloroxylenol ingena engqamuzaneni lebhaktheriya ukuze ihlasele kakhulu ngama-enzyme namaprotheni anele. Uma lokhu kwenziwa, ivala imisebenzi yengqamuzana.

Kuzofika ezingeni lapho inani elikhulu le-Chloroxylenol lifakwa khona kumaseli aqhekekayo okuholela ekufeni kwawo.

Ukuguqulwa kwe-Chloroxylenol

Ukuze kuqinisekiswe kahle ukuthi i-Chloroxylenol iyi-agent elwa namagciwane futhi ebulala amagciwane, izilwane zasetshenziswa ukutadisha ngokugcwele umsebenzi wamandla ayo.

Ukuhlolwa kwesilwane kubonise ukuthi ngenxa yokusetshenziswa kwe-Chloroxylenol esikhumbeni, izinga lokucwiliswa lalishesha kakhulu emahoreni amabili okuqala.

Kwaphawulwa nokuthi into enikezwa izilwane yayikhishwa ngezinso futhi cishe yasuswa ngokuphelele ngesivinini samahora angama-24.

Ingxenye ebalulekile ekhonjwe kusampula yokuphuma kwegazi ihlanganisa ama-glucuronides nama-sulfate.

Iningi lezihloko zocwaningo mayelana ne-Chloroxylenol liqhathanise umsebenzi wayo ne-antibacterial eyaziwayo futhi esekelwa kahle ebizwa ngokuthi i-triclosan. Umbiko ukhombisile ukuthi ama-glucuronides nawo ayeyingxenye yesampula yokuphuma kwendle kumodeli yomuntu.

Ngaphezu kwalokho, kusukela ocwaningweni lwemodeli yabantu, kwakucatshangwa ukuthi yonke i-5 mg ethathwa emzimbeni yayizochama kuze kufike ku-14% we-glucuronic acid kanye ne-sulfuric acid zingakapheli izinsuku ezintathu.

Kodwa-ke, noma yiliphi inani le-Chloroxylenol elifakwa ohlelweni lizogaywa kamuva yisibindi bese likhishwa njenge-sulfate kanye ne-glucuronic derivatives.

Indlela Yokususa

Njengoba kungabonakala ngenhla ezifundweni ezenziwe nge-Chloroxylenol zibonisa ukuthi indlela eyinhloko i-chloroxylenol ekhishwa ngayo ohlelweni ngemva kokusetshenziswa iwukuchama.

Nakuba, inani elincane kakhulu licatshangwa ukuthi lisenyongweni kanti inani elincane kakhulu lisemoyeni ophefumulayo.

Ingabe udinga i-Chloroxylenol?

NgomusaChofoza laphanamuhlaI-Chloroxylenolngayo yonke imikhiqizo yakho yokubulala amagciwane kanye neyokubulala amagciwane, futhi sizojabula kakhulu ukubambisana nawe ukuthola imikhiqizo engcono kakhulu.