I-Pharmacodynamics yeChloroxylenol

I-Chloroxylenol, noma i-para-chloro-meta-xylenol (PCMX), iyi-ejenti eyaziwa kakhulu yokulwa namagciwane kanye nenzalo.Kuyi-ejenti yokuhlanza esetshenziswa ethiyetha yasesibhedlela ukuhlanza izinsiza zokuhlinza.

I-Chloroxylenol ingesinye sezithako ezisebenzayo ezisetshenziswa ekwenzeni insipho ebulala amagciwane.Futhi, ukusetshenziswa kwayo kunqamula abezokwelapha nabasekhaya njengesibulala-magciwane.

Ngokohlu lwe-World Health Organization's List of Essential Medicines, ukuthambekela kwe-chloroxylenol ngokumelene nohlobo lwamagciwane aziwa ngokuthi i-Gram-positive, kubhalwe kahle.

Kodwa-ke, ingabe udinga i-ejenti enhle yokulwa namagciwane kanye nesibulala-magciwane ngezidingo zakho zasendlini nesesibhedlela, lapho-ke kufanele uthinte umuntu onedumela elihle.i-chloroxylenolumkhiqizi.

Inkomba ye-Pharmacological ye-Chloroxylenol

Izicelo ze-Chloroxylenol zivezwa kahle emkhakheni wezokwelapha.

Phambilini ibisetshenziswa ekwelapheni izifo zesikhumba njengokuklwebheka, ukusikeka, ukulunywa yizilwane, ukuntinyela, nesicoci sesandla.

I-Pharmacodynamics yeChloroxylenol

I-Chloroxylenoliyi-phenol esikhundleni, okusho ukuthi ineqembu le-hydroxyl esakhiweni sayo.

Ukusetshenziswa kwayo kwaziwa kakhulu eminyakeni edlule njengenye yezingxenye ezisebenzayo zemikhiqizo ebulala amagciwane.Ukusetshenziswa kwayo kuhlongozwa ngaphandle kweseli.

Umsebenzi wayo we-antimicrobial ngenani elincane eqenjini lamabhaktheriya ubikwa.

Indlela Yokwenza

Ukuba khona kwamaqembu e-hydroxyl esakhiweni sayo kubaluleke kakhulu, ikakhulukazi uma amandla ayo ekhemisi kufanele achazwe.

Iqembu le-hydroxyl kucatshangwa ukuthi linamathisele kumasayithi okubopha amaprotheni, okubuye kube usizo ekuvimbeleni ibhaktheriya elihlaselayo.

I-Chloroxylenol ingena esitokisini sebhaktheriya ukuze ihlasele kakhulu ngama-enzyme namaprotheni anele.Uma lokhu sekwenziwe, kwenza imisebenzi yeseli ingasebenzi.

Izofika ezingeni lapho inani eliphezulu le-Chloroxylenol lisetshenziswa kuma-clot cells okuholela ekufeni kwawo.

I-Metabolism ye-Chloroxylenol

Ukuze kubhalwe kahle i-Chloroxylenol njenge-ejenti yebhaktheriya nesibulala-magciwane, izilwane zasetshenziswa ukutadisha ngokugcwele umsebenzi wamandla ayo.

Ukuhlolwa kwezilwane kwabonisa ukuthi ngenxa yokusetshenziswa kwesikhumba se-Chloroxylenol, izinga lokucwiliswa lalishesha kakhulu phakathi namahora amabili okuqala.

Kuphinde kwaqashelwa ukuthi into enikezwe izilwane yayichama ngenso futhi icishe isuswe ngokuphelele ngesivinini esingamahora angama-24.

Isici esibalulekile esikhonjwe kusampula esilahliwe sihlanganisa ama-glucuronides nama-sulfate.

Iningi lama-athikili ocwaningo mayelana ne-Chloroxylenol liqhathanise umsebenzi wayo ne-antibacterial eyaziwayo futhi ehlonishwa kakhulu ebizwa ngokuthi i-triclosan.Umbiko ukhombisile ukuthi ama-glucuronides nawo abeyingxenye yesampula elikhishwe indle kumodeli yomuntu.

Ngaphezu kwalokho, ocwaningweni lwemodeli yomuntu, kwacatshangwa ukuthi wonke ama-5 mg athathwa emzimbeni azochama afinyelela ku-14% we-glucuronic acid ne-sulfuric acid zingakapheli izinsuku ezintathu.

Kodwa-ke, noma yiliphi inani le-Chloroxylenol elifakwe ohlelweni kamuva lizogaywa yisibindi futhi likhishwe njengokukhishwa kwe-sulfate kanye ne-glucuronic.

Umzila Wokuqedwa

Njengoba kungabonwa ngenhla ocwaningweni olwenziwe nge-Chloroxylenol kukhombisa ukuthi indlela eyinhloko i-chloroxylenol ekhishwa ngayo ohlelweni ngemuva kokuphathwa ngomchamo.

Nakuba, inani elincane kakhulu kucatshangwa ukuthi liku-bile kanye nenani elincane kakhulu emoyeni ophefumulelwe.

Ingabe udinga i-Chloroxylenol?

NgomusaChofoza laphanamuhla ngobaI-Chloroxylenolngayo yonke imikhiqizo yakho yokubulala amagciwane kanye nesibulala-magciwane, futhi sizojabula kakhulu ukubambisana nawe ngemikhiqizo engcono kakhulu.