Yaziwa ngokuthi "ngegolide elimhlophe", futhi idumela layo lilele emthonjeni walo mhlophe ongenakuqhathaniswa ngakolunye uhlangothi, nobunzima kanye nobunzima bokukhishwa kwalo kolunye. Isitshalo Glycyrriza Glabra singumthombo weGlabridin, kepha i-Glabridin kuphela ama-akhawunti angu-0,1% -0.3% wokuqukethwe kwawo konke, okusho ukuthi, i-1000kg ye-glycyrrhiza glabra ingathola kuphela i-100g yeGlabridin, I-1g ye-Glabridin ilingana ne-1g yegolide elingokomzimba.
I-Hikarigandine ingummeleli ojwayelekile wezithako zamakhambi, futhi umphumela waso mhlophe utholakele yiJapan
UGlycyrrhiza Glabra uyisitshalo sohlobo lwe-glycyrrriza. I-China yizwe elinezinsizakusebenza zamakhambi ezicebile emhlabeni, futhi kunezinhlobo ezingaphezu kuka-500 zamakhambi asetshenziswa ekusebenzeni emtholampilo, phakathi kwazo ezisetshenziswa kakhulu yi-licorice. Ngokusho kwezibalo, inani lokusebenzisa le-licorice lingaphezu kwama-79%.
Ngenxa yomlando omude wesicelo, ehambisana nedumela eliphakeme, ubukhulu bokucwaninga ngenani le-licorice agcineki kuphela ngemikhawulo yendawo, kodwa futhi nesicelo sekwandisiwe. Ngokokucwaninga, abathengi base-Asia, ikakhulukazi eJapan, banenhlonipho enkulu yezimonyo eziqukethe izithako ezisebenzayo ze-herbal. 114 Izithako zezimonyo ze-Herbal zibhalwe ku- "Japan General COSMETICS izinto zokwakha", futhi sekuvele kunezinhlobo ezingama-200 zezimonyo eziqukethe izithako zamakhambi eJapan.
Kwamukelwa ukuthi ube nomphumela omkhulu onzima, kepha yini ubunzima ngohlelo lokusebenza olusebenzayo?
Ingxenye ye-hydrophobic ye-licorice extract iqukethe ama-flavonoid ahlukahlukene. Njengengxenye eyinhloko yengxenye yayo ye-hydrophobic, i-halo-glycyrrhidine inomthelela ovimbayo ku-melanin ukukhiqizwa futhi inakho nemiphumela yokulwa nokuvuvukala kanye nama-anti-oxidant.
Eminye imininingwane yokuhlola ikhombisa ukuthi umphumela onzima we-Light Glabridin uphakeme izikhathi ezingama-232 ukwedlula lokho ngamavithamini C ajwayelekile kunalokho kwe-hydroquinone kunalokho kwe-hydroquinone, kanye nezikhathi eziyi-1,164 eziphakeme kunalezo ze-Arbutin. Ukuthi ungafinyelela kanjani umsebenzi onzima onamandla, ukukhanya kwe-glabridin kunikeza izindlela ezintathu ezahlukene.
1. Ukuvinjwa komsebenzi weTyrosinase
Indlela enkulu emhlophe yeGlabridinUkuvimbela ukuhlanganiswa kwe-melanin ngokuvimbela umsebenzi wokuncintisana kwe-tyrosinase, kususa ingxenye ye-tyrosinase kusuka ku-catalytic ring of melanin synthesis futhi ivimbela ukubopha kwe-substrate eTyrosinase.
2. Umphumela we-Antioxidant
Kungavimba umsebenzi womsebenzi we-tyrosinase ne-dopa kanye nomsebenzi we-dihydroxyimodiyole carboxylic acid oxidase.
Kukhonjiswe ukuthi ekuhlolweni kwe-0.1MG / ML, i-PhotoGlyCyrrridine ingasebenza ngohlelo lwe-cytochrome P450 / nadoh oxidation system futhi i-scavenge 67% yama-antioxidant umsebenzi wamahhala.
3.Ibhibibisi izici zokuvuvukala nokulwa ne-UV
Njengamanje, ucwaningo oluncane lubikwe ukusetshenziswa kwe-PhotoGlyCyrridine esifundweni sezithombe zesikhumba ezibangelwe ngu-UV. Ngo-2021, esihlokweni esise-Core Journal Journal Journal se-Microbiology kanye ne-biotechnynology, i-photoglycycyrridine liposomes afunwa amandla awo okukhanyisela i-erythema nesifo sesikhumba ngokuvimbela izici zokuvuvukala. I-PhotoGlyCyrrrrine Liposomes ingasetshenziswa ukuthuthukisa ama-bioavailebility nge-cytotoxicicity encane ngokuvinjwa kwe-melanin, i-Impevuukin 10. Ngakho-ke, ingasetshenziswa njenge-ejensi yokwelapha ethosiwe yokulwa nokulimala kwesikhumba okuvinjelwe, okunganikezwa eminye imibono yocwaningo lokukhanya kwelanga imikhiqizo evikelekile yokuvikela.
Ngamafuphi, umphumela wamhlophe we-photoGlyCyrrridine wamukelwa, kepha imvelo yawo icishe ibekwe phansi emanzini, ngakho-ke iyakufuna ikakhulukazi ukukhiqizwa kokukhiqizwa komkhiqizo, futhi okwamanje kuyisisombululo esihle nge-liposome technology. Ngaphezu kwalokho, isithombeGlabridinAma-liposomes angavimba izithombe ezibangelwa i-UV, kepha lo msebenzi udinga izivivinyo zemitholampilo eziqinisekisiwe zokuqinisekiswa kanye nezinhlelo zokusebenza zocwaningo ezizosetshenziswa.
Imikhiqizo yokunakekelwa kwesikhumba equkethe i-Photoglabrin ngesimo sokuhlanganiswa kwezithako.
Ngenkathi kungabaza ukuthi i-PhotocLabridine inomphumela omuhle kakhulu mhlophe, intengo yayo engavuthiwe nayo iyavinjelwa ngenxa yobunzima ekukhishweni nokuqukethwe. Ku-cosmetic R & D, umsebenzi wezindleko ezilawulayo uxhunyaniswa ngokuqondile kokuqukethwe kwezobuchwepheshe nenqubo yesayensi. Ngakho-ke, kuyindlela enhle yokulawula izindleko zokwakhiwa kanye nokufeza ikhwalithi ephephile nesebenzayo ngokukhetha izithako ezisebenzayo futhi uzihlanganise ngokuhlanganisa nge-photoGlyCyrrine. Ngaphezu kwalokho kwiveli ye-R & D, okuqhubekayo kuyadingeka maqondana nocwaningo lwe-PhotoGlyCyrrine Liposomes kanye namasu wakamuva wokukhipha.
Isikhathi sePosi: Aug-30-2022