Yake yaziwa ngokuthi "igolide elimhlophe", futhi isithunzi sayo sisemphumela wayo wokuba mhlophe ongenakuqhathaniswa ngakolunye uhlangothi, kanye nobunzima kanye nokushoda kokukhishwa kwayo ngakolunye. Isitshalo i-Glycyrrhiza glabra siwumthombo we-Glabridin, kodwa i-Glabridin ihlanganisa kuphela u-0.1% -0.3% wokuqukethwe kwayo konke, okusho ukuthi, i-1000kg ye-Glycyrrhiza glabra ingathola kuphela i-100g yeI-Glabridin, 1g ye-Glabridin ilingana ne-1g yegolide elibonakalayo.
I-Hikarigandine ingummeleli ojwayelekile wezithako zemithi, futhi umphumela wayo wokuba mhlophe utholwe yiJapan
I-Glycyrrhiza glabra isitshalo sohlobo lwe-Glycyrrhiza. I-China yizwe elinemithombo yemithi ecebe kakhulu emhlabeni, futhi kunezinhlobo ezingaphezu kuka-500 zamakhambi asetshenziswa emitholampilo, phakathi kwazo ezisetshenziswa kakhulu i-licorice. Ngokwezibalo, izinga lokusetshenziswa kwe-licorice lingaphezu kwama-79%.
Ngenxa yomlando omude wohlelo lokusebenza, ohambisana nedumela eliphezulu, ububanzi bocwaningo mayelana nenani le-licorice alizange liphule imingcele yendawo kuphela, kodwa futhi isicelo sandisiwe. Ngokocwaningo, abathengi base-Asia, ikakhulukazi eJapane, bazihlonipha kakhulu izimonyo eziqukethe izithako ezisebenzayo zemithi. Izithako eziyi-114 zezimonyo zezimonyo zirekhodwe ku-"General Cosmetics Raw Materials yaseJapan", futhi sekuvele kunezinhlobo ezingama-200 zezimonyo eziqukethe izithako zekhambi eJapan.
Kuqashelwa ukuthi kunomphumela omhlophe kakhulu, kepha ibuphi ubunzima ekusebenziseni okungokoqobo?
Ingxenye ye-hydrophobic ye-licorice ekhishwe iqukethe ama-flavonoid ahlukahlukene. Njengengxenye eyinhloko yengxenye yayo ye-hydrophobic, i-halo-glycyrrhizidine inomphumela ovimbelayo ekukhiqizeni i-melanin futhi inemiphumela yokulwa nokuvuvukala kanye ne-anti-oxidant.
Enye idatha yokuhlola ibonisa ukuthi umphumela wokuba mhlophe we-Glabridin okhanyayo uphakeme ngokuphindwe izikhathi ezingu-232 kunalowo wevithamini C evamile, izikhathi ezingu-16 ngaphezu kwalokho we-hydroquinone, futhi izikhathi ezingu-1,164 ziphakeme kune-arbutin. Mayelana nokuthi ungawufinyelela kanjani umsebenzi wokuba mhlophe onamandla, i-Glabridin ekhanyayo inikeza izindlela ezintathu ezihlukene.
1. Ukuvinjelwa komsebenzi we-tyrosinase
Indlela yokwenza mhlophe eyinhloko yeI-Glabridinukuvimbela ukwakheka kwe-melanin ngokuncintisana ngokuvimbela umsebenzi we-tyrosinase, ukususa ingxenye ye-tyrosinase eringini ye-catalytic ye-melanin synthesis kanye nokuvimbela ukuboshwa kwe-substrate ku-tyrosinase.
2. Umphumela we-Antioxidant
Ingavimbela kokubili umsebenzi we-tyrosinase kanye ne-dopa pigment interchange kanye nomsebenzi we-dihydroxyindole carboxylic acid oxidase.
Kuboniswe ukuthi ekuhlanganiseni kwe-0.1mg/ml, i-photoglycyrrhizidine ingakwazi ukusebenza ohlelweni lwe-oxidation ye-cytochrome P450/NADOH futhi ikhiphe u-67% wama-radicals mahhala, anomsebenzi onamandla we-antioxidant.
3.Vimbela izici ezivuthayo futhi ulwe ne-UV
Njengamanje, ucwaningo oluncane luye lwabikwa ngokusetshenziswa kwe-photoglycyrrhizidine ocwaningweni lwe-UV-induced skin photoaging. Ngo-2021, ku-athikili kujenali eyinhloko i-Journal of Microbiology and Biotechnology, ama-photoglycyrrhizidine liposomes acwaningwa ngekhono lawo lokuthuthukisa i-UV ebangelwa ukukhanya kwe-erythema nesifo sesikhumba ngokuvimbela izici ezivuthayo. I-Photoglycyrrhizidine liposomes ingasetshenziswa ukuthuthukisa i-bioavailability nge-cytotoxicity encane kanye nokuvinjelwa okungcono kwe-melanin, ukwehlisa ngokuphumelelayo ukubonakaliswa kwama-cytokines avuthayo, i-interleukin 6 kanye ne-interleukin 10. Ngakho-ke, ingasetshenziswa njenge-ejenti yokwelapha ye-topical ukuze imelane nokuvuvukala okubangelwa imisebe ye-UV esikhumbeni esivikela ukukhanya kwe-UV esikhumbeni esivikela ukuvikela okumhlophe okungase kunikeze ukuvikela okumhlophe kwesikhumba okubangelwa ukucwaninga ngemibono emhlophe. imikhiqizo.
Kafushane, umphumela omhlophe we-photoglycyrrhizidine uyabonakala, kodwa imvelo yawo cishe ayincibiliki emanzini, ngakho-ke idinga kakhulu inqubo yokukhiqiza nokukhiqiza ekusetshenzisweni komkhiqizo wokunakekelwa kwesikhumba, futhi okwamanje iyisixazululo esihle ngokusebenzisa ubuchwepheshe be-liposome encapsulation. Ngaphezu kwalokho, isithombeI-Glabridinama-liposomes angavimbela ukuthwebula izithombe okubangelwa yi-UV, kodwa lo msebenzi udinga ukuhlolwa okwengeziwe komtholampilo ukuze kuqinisekiswe futhi kusetshenziswe izicelo zocwaningo.
Imikhiqizo yokunakekelwa kwesikhumba equkethe isithombeGlabridin ngendlela yokuhlanganisa isithako.
Nakuba kungangabazeki ukuthi i-photoGlabridine inomphumela omuhle kakhulu wokwenza mhlophe, intengo yayo yezinto ezingavuthiwe nayo iyanqanda ngenxa yobunzima bokukhipha nokuqukethwe. Ku-R&D yezimonyo, umsebenzi wokulawula izindleko uxhunywe ngokuqondile nokuqukethwe kwezobuchwepheshe kanye nenqubo yesayensi. Ngakho-ke, kuyindlela enhle yokulawula izindleko zokubunjwa nokufeza ikhwalithi ephephile nephumelelayo ngokukhetha izithako ezisebenzayo futhi uzihlanganise ekuhlanganiseni ne-photoglycyrrhizidine. Ukwengeza ezingeni le-R&D, ukuhlolwa okwengeziwe kuyadingeka mayelana nocwaningo lwe-photoglycyrrhizidine liposomes kanye nezindlela zakamuva zokukhipha.
Isikhathi sokuthumela: Aug-30-2022