Ngaphambili yayaziwa ngokuthi "igolide elimhlophe", futhi idumela layo lisekusebenzeni kwayo okumhlophe okungenakuqhathaniswa ngakolunye uhlangothi, kanye nobunzima kanye nokuntuleka kokukhishwa kwayo kolunye uhlangothi. Isitshalo i-Glycyrrhiza glabra siwumthombo we-Glabridin, kodwa i-Glabridin ikhiqiza kuphela u-0.1%-0.3% wokuqukethwe kwayo okuphelele, okungukuthi, i-1000kg ye-Glycyrrhiza glabra ingathola kuphela u-100g we-I-Glabridin, i-1g ye-Glabridin ilingana ne-1g yegolide elingokoqobo.
I-Hikarigandine ingummeleli ojwayelekile wezithako zezitshalo, futhi umphumela wayo wokuba mhlophe utholakala eJapan
I-Glycyrrhiza glabra iyisitshalo sohlobo lwe-Glycyrrhiza. I-China iyizwe elinemithombo yamakhambi ecebile kakhulu emhlabeni, futhi kunezinhlobo zamakhambi ezingaphezu kuka-500 ezisetshenziswa emtholampilo, phakathi kwazo ezisetshenziswa kakhulu yi-licorice. Ngokwezibalo, izinga lokusetshenziswa kwe-licorice lingaphezu kuka-79%.
Ngenxa yomlando omude wokusetshenziswa, okuhambisana nedumela eliphezulu, ububanzi bocwaningo ngenani le-licorice abuzange budlule nje kuphela emikhawulweni yendawo, kodwa futhi nokusetshenziswa kwandisiwe. Ngokusho kocwaningo, abathengi e-Asia, ikakhulukazi eJapane, bahlonipha kakhulu izimonyo eziqukethe izithako ezisebenzayo zamakhambi. Izithako zezimonyo zamakhambi ezingu-114 ziqoshwe ku-"Japan's General Cosmetics Raw Materials", futhi kakade kunezinhlobo ezingu-200 zezimonyo eziqukethe izithako zamakhambi eJapane.
Kuyaziwa ukuthi kunomphumela omuhle kakhulu wokwenza kube mhlophe, kodwa yiziphi izinkinga ekusetshenzisweni okungokoqobo?
Ingxenye engathathi hlangothi ye-licorice extract iqukethe ama-flavonoid ahlukahlukene. Njengengxenye eyinhloko yengxenye yayo engathathi hlangothi, i-halo-glycyrrhizidine inomphumela wokuvimbela ekukhiqizweni kwe-melanin futhi inemiphumela yokulwa nokuvuvukala kanye ne-anti-oxidant.
Olunye ulwazi lokuhlola lubonisa ukuthi umphumela wokwenza mhlophe we-Glabridin ekhanyayo uphakeme ngokuphindwe ka-232 kunowe-vitamin C evamile, uphakeme ngokuphindwe ka-16 kunowe-hydroquinone, kanye nophakeme ngokuphindwe ka-1,164 kunowe-arbutin. Mayelana nendlela yokufeza umsebenzi wokwenza mhlophe onamandla, i-Glabridin ekhanyayo inikeza izindlela ezintathu ezahlukene.
1. Ukuvinjelwa komsebenzi we-tyrosinase
Indlela eyinhloko yokwenza mhlopheI-Glabridinukuvimbela ukwakheka kwe-melanin ngokuvimbela ngokuncintisana umsebenzi we-tyrosinase, ukususa ingxenye ye-tyrosinase eringini ye-catalytic yokwakheka kwe-melanin nokuvimbela ukubopha kwe-substrate ku-tyrosinase.
2. Umphumela we-Antioxidant
Kungavimbela kokubili umsebenzi we-tyrosinase kanye ne-dopa pigment exchange kanye nomsebenzi we-dihydroxyindole carboxylic acid oxidase.
Kuye kwaboniswa ukuthi ekugxilweni okungu-0.1mg/ml, i-photoglycyrrhizidine ingasebenza ohlelweni lwe-cytochrome P450/NADOH oxidation futhi isuse ama-free radical angu-67%, anomsebenzi onamandla we-antioxidant.
3.Vimbela izinto ezibangela ukuvuvukala futhi ulwe ne-UV
Njengamanje, ucwaningo oluncane luye lwabikwa ngokusetshenziswa kwe-photoglycyrrhizidine ocwaningweni lwe-UV-induced skin photoaging. Ngo-2021, esihlokweni esikumagazini oyinhloko i-Journal of Microbiology and Biotechnology, ama-liposome e-photoglycyrrhizidine afundwe ngekhono lawo lokuthuthukisa i-erythema ebangelwa ukukhanya kwe-UV kanye nesifo sesikhumba ngokuvimbela izici zokuvuvukala. Ama-liposome e-Photoglycyrrhizidine angasetshenziswa ukuthuthukisa ukutholakala kwe-bioavailability nge-cytotoxicity encane kanye nokuvinjelwa okungcono kwe-melanin, okunciphisa ngempumelelo ukubonakaliswa kwama-cytokines okuvuvukala, i-interleukin 6 kanye ne-interleukin 10. Ngakho-ke, ingasetshenziswa njenge-ejenti yokwelapha engaphandle ukulwa nomonakalo wesikhumba obangelwa imisebe ye-UV ngokuvimbela ukuvuvukala, okungase kunikeze imibono ethile yocwaningo lwemikhiqizo yokuvikela ukukhanya kwelanga.
Ngamafuphi, umphumela wokuba mhlophe we-photoglycyrrhizidine uyabonakala, kodwa uhlobo lwayo aluncibiliki emanzini, ngakho-ke ludinga kakhulu inqubo yokukhiqiza nokukhiqiza ekusetshenzisweni kokwengezwa komkhiqizo wokunakekelwa kwesikhumba, futhi okwamanje luyisisombululo esihle ngobuchwepheshe be-liposome encapsulation. Ngaphezu kwalokho, isithombeI-GlabridinAma-liposome angavimbela ukuguga kwezithombe okubangelwa yi-UV, kodwa lo msebenzi udinga ukuhlolwa okwengeziwe kwemitholampilo ukuze kuqinisekiswe futhi kusetshenziswe izinhlelo zocwaningo.
Imikhiqizo yokunakekela isikhumba equkethe i-photoGlabridin ngendlela yokuhlanganiswa kwezithako.
Nakuba kungekho kungabaza ukuthi i-photoGlabridine inomphumela omuhle kakhulu wokwenza mhlophe, intengo yayo yezinto zokusetshenziswa nayo iphakeme ngenxa yobunzima bokukhipha nokuqukethwe. Ku-R&D yezimonyo, umsebenzi wokulawula izindleko uhlobene ngqo nokuqukethwe kobuchwepheshe kanye nenqubo yesayensi. Ngakho-ke, kuyindlela enhle yokulawula izindleko zamafomula nokufeza ikhwalithi ephephile nephumelelayo ngokukhetha izithako ezisebenzayo nokuzihlanganisa ekuhlanganisweni ne-photoglycyrrhizidine. Ngaphezu kwalokho ezingeni le-R&D, kudingeka ukuhlolwa okwengeziwe mayelana nocwaningo lwe-photoglycyrrhizidine liposomes kanye namasu akamuva okukhipha.
Isikhathi sokuthunyelwe: Agasti-30-2022