I-Triclosaniyi-antimicrobial ye-spectrum ebanzi esetshenziswa njengesibulala-magciwane, isibulala-magciwane noma isilondolozi kuzilungiselelo zomtholampilo, imikhiqizo ehlukahlukene yabathengi ehlanganisa izimonyo, imikhiqizo yokuhlanza yasendlini, izinto zepulasitiki, amathoyizi, upende, njll. Ibuye ifakwe ebusweni bemishini yezokwelapha, izinto zepulasitiki, izindwangu, izitsha zasekhishini, njll., lapho ingase iphume kancane kancane isikhathi eside phakathi nokusetshenziswa kwazo, ukwenza isenzo sayo se-biocidal.
Isetshenziswa kanjani i-triclosan kuzimonyo?
I-Triclosanyafakwa ohlwini ngo-1986 ku-European Community Cosmetics Directive ukuze isetshenziswe njengesilondolozi emikhiqizweni yezimonyo ekugxilweni okufika ku-0.3%.Ukuhlolwa kwengozi kwakamuva okwenziwa yiKomidi Lezesayensi Le-EU Lemikhiqizo Yabathengi kuphethe ngokuthi, nakuba ukusetshenziswa kwayo kusezingeni eliphezulu elingu-0.3% kumithi yokuxubha, izinsipho zezandla, izinsipho zomzimba/amajeli eshawa kanye nezinti zesiqedaphunga kubhekwa njengokuphephile endaweni enobuthi. imikhiqizo ngayinye, ubukhulu bokuchayeka okuhlanganisiwe ku-triclosan kusuka kuyo yonke imikhiqizo yezimonyo akuphephile.
Noma yikuphi ukusetshenziswa okwengeziwe kwe-triclosan kuzimpushana zobuso nezinto zokufihla amabala kulokhu kugxilwa nakho kwathathwa njengokuphephile, kodwa ukusetshenziswa kwe-triclosan kweminye imikhiqizo yeleveli (isb. ama-lotions omzimba) nasezixukwini zokugeza umlomo akuzange kubhekwe njengokuphephile kumthengi ngenxa yomphumela ophezulu. ukuchayeka.Ukuchayeka ekuhogeleni ku-triclosan emikhiqizweni yesifutho (isb. ama-deodorants) akuzange kuhlolwe.
I-Triclosanekubeni engeyona i-ionic, ingakhiwa kuma-dentfrices avamile.Kodwa-ke, ayibophezeli ezindaweni zomlomo isikhathi esingaphezu kwamahora ambalwa, ngakho-ke ayilethi izinga eliqhubekayo lomsebenzi wokulwa nama-plaque.Ukwandisa ukumuncwa nokugcinwa kwe-triclosan ngezindawo zomlomo ukuze kuthuthukiswe ukulawulwa kwe-plaque nempilo ye-gingival, i-triclosan/polyvinylmethyl ether maleic acid copolymer kanye ne-triclosan/zinc citrate kanye ne-triclosan/calcium carbonate dentifrice isetshenziswa.
Isetshenziswa kanjani i-triclosan ekunakekelweni kwezempilo nakumadivaysi ezokwelapha?
I-Triclosanisetshenziswe ngempumelelo emtholampilo ukuze kuqedwe izinto ezincane ezifana ne-methicillin-resistant Staphylococcus aureus (MRSA) , ikakhulukazi ngesincomo sokusebenzisa ukugeza kwe-triclosan okungu-2%.I-Triclosan isetshenziswa njengezikhuhla zokuhlinza, futhi isetshenziswa kakhulu ekugeza izandla nanjengokugeza umzimba ukuze kuqedwe i-MRSA kubathwali ngaphambi kokuhlinzwa .
I-Triclosan isetshenziswa emishinini eminingi yezokwelapha, ngokwesibonelo ama-stents e-urethra, ama-suture okuhlinzwa futhi angase acatshangelwe ukuvimbela ukutheleleka nge-graft.U-Bojar et al akazange abone umehluko ekoloni phakathi kwe-triclosan-coated sutures kanye ne-multifilament suture evamile, nakuba umsebenzi wabo uthinta amabhaktheriya amahlanu futhi usekelwe kuphela ekunqumeni kwendawo yokuvimbela.
Kuma-stents e-ureter, i-triclosan iboniswe ukuthi ivimbela ukukhula kwe-uropathogens yebhaktheriya evamile futhi inciphise izehlakalo zokutheleleka kwe-urinary-tract futhi, okungenzeka, ukufakwa kwe-catheter muva nje kubonise imiphumela ye-synergistic ye-triclosan kanye nama-antibiotic afanelekile kuma-isolate omtholampilo ahlanganisa izinhlobo eziyisikhombisa ze-uropathogenic, futhi basekela ukusetshenziswa kwe-triclosan-eluting stent lapho kudingekile, kanye nokwelashwa okujwayelekile kwama-antibiotic ekwelapheni iziguli eziyinkimbinkimbi.
Kwezinye intuthuko eyengeziwe, ukusetshenziswa kwe-triclosan ku-Foley catheter yomchamo kwaphakanyiswa njengoba i-triclosan ivimbele ngempumelelo ukukhula kwe-Proteus mirabilis kanye nokulawulwa kokufakwa nokuvinjwa kwe-catheter.Muva nje, uDarouiche et al.ibonise umsebenzi wokulwa namagciwane ohlangene, obanzi futhi oqinile wama-catheter ahlanganiswe nenhlanganisela ye-triclosan ne-DispersinB, i-enzyme elwa ne-biofilm evimbela futhi ihlakaze ama-biofilms.
Isetshenziswa kanjani i-triclosan kweminye imikhiqizo yabathengi?
Umsebenzi we-triclosan we-antimicrobial obanzi uholele ekufakweni kwayo ohlwini olunwetshiwe lwemikhiqizo ehloselwe ukusetshenziswa ekhaya njengezinsipho eziwuketshezi, okokuhlanza, amabhodi okunquma, amathoyizi ezingane, okhaphethi neziqukathi zokugcina ukudla.Uhlu oluningiliziwe lwemikhiqizo yabathengi equkethe i-triclosan luhlinzekwa yi-US Environmental Protection Agency (EPA) kanye nama-NGOs ase-US "Iqembu Lokusebenza Kwezemvelo" kanye "Ngaphandle Kwemithi Yezinambuzane" .
Inani elikhulayo lezimpahla zokugqoka liphathwa ngama-biocides.I-Triclosan ingenye ye-ejenti yokuqeda ukukhiqizwa kwezindwangu ezinjalo .Izindwangu eziqedwe nge-triclosan ziphathwa ngama-agent axhumanisa ukuhlinzeka ngezindawo ezihlala njalo ze-antibacterial.Ngokwesisekelo solwazi olutholakalayo, imikhiqizo engu-17 evela emakethe yokudayisa yaseDenmark yahlaziywa ukuze kutholwe okuqukethwe kwezinye izinhlanganisela ezikhethiwe zokulwa namagciwane: i-triclosan, i-dichlorophen, i-Kathon 893, i-hexachlorophen, i-triclocarban ne-Kathon CG.Emihlanu yemikhiqizo itholwe iqukethe u-0.0007% - 0.0195% we-triclosan.
U-Aiello et al ekubuyekezweni kokuqala okuhlelekile okuhlola inzuzo yezinsipho eziqukethe i-triclosan, kuhlolwe izifundo ezingu-27 ezishicilelwe phakathi kuka-1980 no-2006. Okunye okutholakele okubalulekile ukuthi insipho equkethe ngaphansi kwe-triclosan engaphansi kwe-1% ayizange ibonise inzuzo ezinsipho ezingezona ezilwa namagciwane.Ucwaningo olusebenzisa insipho equkethe > 1% i-triclosan lubonise ukwehla okukhulu kumazinga ebhaktheriya esandleni, ngokuvamile ngemva kokusetshenziswa okuningi.
Ukushoda okusobala kobudlelwane phakathi kokusetshenziswa kwensipho equkethe i-triclosan kanye nokwehliswa kwezifo ezithathelwanayo bekunzima ukukucacisa ngaphandle kokuhlonza ama-ejenti webhayoloji anesibopho sezimpawu zokugula.Ucwaningo olubili lwakamuva lwase-US lubonise ukuthi ukugeza izandla ngensipho elwa namagciwane equkethe i-triclosan (0.46%) kwehlisa umthamo webhaktheriya kanye nokudluliselwa kwamagciwane ezandleni, uma kuqhathaniswa nokugeza izandla ngensipho engaphilisi amagciwane.
Imikhiqizo Yasentwasahlobo
Sikhiqiza imikhiqizo eminingi engasetshenziswa ekunakekelweni komuntu siqu kanye nemboni yezimonyo, njengokunakekelwa kwesikhumba, ukunakekelwa kwezinwele, ukunakekelwa komlomo, izimonyo, ukuhlanza indlu, okokuhlanza kanye nokunakekelwa kwempahla, ukuhlanza isibhedlela kanye nesikhungo somphakathi.Xhumana nathi manje uma ufuna uzakwethu webhizinisi othembekile.
Isikhathi sokuthumela: Jun-10-2021