I-Action Mechanism_ Izinhlobo kanye nezinkomba zokuhlola zezinto zokugcina

Ngezansi isingeniso esifushane mayelana nezindlela zokusebenza, izinhlobo kanye nokuhlolwa okuqondiswe ezivikelweni ezahlukene zokulondolozwa

1.Indlela yokusebenza iyonkeizilondolozi

Izithako zokulondoloza ziyizinto ezisetshenziswa kakhulu ngamakhemikhali ezisiza ukubulala noma ukuvimbela imisebenzi yamagciwane ezimonyweni kanye nokugcina ikhwalithi iyonke yezimonyo isikhathi eside.

Kodwa-ke, kufanele kuqashelwe ukuthi izilondolozi aziwona ama-bactericide ngoba azinawo umphumela oqinile wokubulala amagciwane, futhi zisebenza kuphela uma zisetshenziswa ngobuningi obanele noma uma zithintana ngqo nama-microorganism.

Izithako zokuvikela zivimbela ukukhula kwamagciwane ukuthi zivimbele ukwakheka kwama-enzyme abalulekile e-metabolic kanye nokuvimbela ukwakheka kwamaprotheni ezingxenyeni ezibalulekile zamaseli noma ukwakheka kwe-nucleic acid.

2.Izici ezithinta Imisebenzi Yezilondolozi

Ziningi izinto ezibangela umphumela wezinto zokugcina ukudla. Zihlanganisa;

a.Umphumela we-pH

Ushintsho ku-pH lunegalelo ekuqhekekeni kwezithako zokulondoloza ze-organic acid, ngakho-ke luthinta ukusebenza kahle kwazo zonke izithako zokulondoloza. Isibonelo, ku-pH 4 kanye ne-pH 6, i-2-bromo-2-nitro-1,3-propanediol izinzile kakhulu.

b.Imiphumela yejeli nezinhlayiya eziqinile

I-Koalin, i-magnesium silicate, i-aluminium njll., ezinye izinhlayiya zempuphu ezikhona kwezinye izimonyo, ezivame ukumunca isilondolozi ngakho-ke okuholela ekulahlekelweni komsebenzi yi-preservative. Kodwa-ke, ezinye ziyasebenza futhi ekumunceni amabhaktheriya akhona ku-preservative. Futhi, ukuhlanganiswa kwejeli ye-polymer encibilikayo emanzini kanye nesilondolozi kunegalelo ekunciphiseni ukugcwala kwesilondolozi esisele ekwakhiweni kwezimonyo, futhi lokhu kunciphisa nomphumela wesilondolozi.

c.Umphumela wokuncibilika kwama-surfactants angewona ama-ionic

Ukuncibilikiswa kwama-surfactants ahlukahlukene njenge-surfactants engeyona ionic kuma-preservatives nakho kuthinta umsebenzi ojwayelekile wama-preservatives. Kodwa-ke, ama-surfactants engeyona ionic ancibilikayo kumafutha njenge-HLB=3-6 ayaziwa ukuthi anamandla aphezulu okuvala ukusebenza kuma-preservatives uma kuqhathaniswa nama-surfactants engeyona ionic ancibilikayo emanzini anenani eliphezulu le-HLB.

d.Umphumela wokonakala kokulondolozwa

Kunezinye izici ezifana nokushisa, ukukhanya njll., ezibangela ukuwohloka kwezilondolozi, ngaleyo ndlela kubangele ukwehla komphumela wazo wokubulala amagciwane. Ngaphezu kwalokho, eminye yale miphumela iholela ekusabeleni kwamakhemikhali ngenxa yokuhlanza ngemisebe kanye nokubulala amagciwane.

e.Eminye imisebenzi

Ngokufanayo, ezinye izici ezifana nokuba khona kwezinongo kanye nezinto ezibangela ukubola kanye nokusatshalaliswa kwezithako zokugcina ukudla emanzini kawoyela ngezigaba ezimbili nakho kuzofaka isandla ekunciphiseni umsebenzi wezithako zokugcina ukudla ngezinga elithile.

3.Izakhiwo ze-antiseptic ze-preservatives

Izakhiwo zokubulala amagciwane zemithi yokuvikela zifanele ukucatshangelwa. Ukuba nemithi yokuvikela eningi ezimonyweni kuzokwenza kube yinto ecasulayo, kanti ukuntuleka kokuhlushwa kuzothinta imithi yokubulala amagciwane.izakhiwo zezilondoloziIndlela engcono kakhulu yokuhlola lokhu ukusebenzisa isivivinyo senselelo yezinto eziphilayo esihilela ukuhlushwa okuncane kokuvimbela (i-MIC) kanye nesivivinyo sendawo yokuvimbela.

Ukuhlolwa kwendilinga ye-bacteriostatic: Lokhu kuhlolwa kusetshenziselwa ukuthola lawo mabhaktheriya kanye nesikhunta esinamandla okukhula ngokushesha ngemva kokutshala endaweni efanele. Esimweni lapho idiski yephepha lokuhlunga elifakwe isivikelo liphonswa phakathi kwepuleti lendawo yokukhulisa, kuzoba nombuthano we-bacteriostatic owakhiwe nxazonke ngenxa yokungena kwesivikelo. Uma kulinganiswa ububanzi bendilinga ye-bacteriostatic, ingasetshenziswa njengesilinganiso sokunquma ukusebenza kwesivikelo.

Ngalokhu, kungashiwo ukuthi indilinga ye-bacteriostatic esebenzisa indlela yephepha enobubanzi >=1.0mm iyasebenza kakhulu. I-MIC ibizwa ngokuthi ukuhlushwa okuncane kakhulu kwesilondolozi esingafakwa endaweni yokuvimbela ukukhula kwamagciwane. Esimweni esinjalo, i-MIC encane, kulapho izakhiwo zokulwa namagciwane zesilondolozi ziqina khona.

Amandla noma umphumela womsebenzi wokulwa namagciwane uvame ukubonakaliswa ngesimo se-minimum inhibitory concentration (MIC). Ngokwenza kanjalo, umsebenzi wokulwa namagciwane onamandla unqunywa inani elincane le-MIC. Nakuba i-MIC ingeke isetshenziswe ukuhlukanisa phakathi komsebenzi wokubulala amagciwane kanye nowe-bacteriostatic, ama-surfactants ngokuvamile aziwa ngokuba nomphumela we-bacteriostatic ekugxilweni okuphansi kanye nomphumela wokubulala amagciwane ekugxilweni okuphezulu.

Eqinisweni, ngezikhathi ezahlukene, lezi zenzo ezimbili zenzeka ngesikhathi esisodwa, futhi lokhu kwenza kube nzima ukuzihlukanisa. Ngenxa yalesi sizathu, zivame ukunikezwa igama elihlanganisiwe njengokubulala amagciwane noma ukubulala amagciwane nje.