I-Chlorphenesin

I-Chlorphenesin(104-29-0), igama lamakhemikhali yi-3-(4-chlorophenoxy)propane-1,2-diol, ngokuvamile yenziwa ngokuphendula kwe-p-chlorophenol nge-propylene oxide noma i-epichlorohydrin. Kuyi-ejenti yokulwa namagciwane kanye ne-antibacterial ene-spectrum ebanzi, enomthelela wokulwa namagciwane kumagciwane ane-Gram-positive, amagciwane ane-Gram-negative, imvubelo kanye nezikhunta. Ivunyelwe ukusetshenziswa ezimonyweni zamakhemikhali ngamazwe amaningi nezifunda ezifana neYurophu, i-United States, iJapan, kanye neShayina. Umkhawulo wokusetshenziswa ovunyelwe yimithetho nemigomo eminingi kazwelonke ngu-0.3%.
I-ChlorphenesinEkuqaleni yayingasetshenziswa njengesivikelo, kodwa njenge-antigen-related immunosuppressant evimbela ukukhishwa kwe-histamine ebangelwa yi-IgE embonini yezemithi. Kalula nje, ilwa nokungezwani komzimba. Kusukela ngo-1967, imboni yezemithi yayifunde ukusetshenziswa kwe-chlorphenesin ne-penicillin ukuvimbela ukusabela kokungezwani komzimba okubangelwa yi-penicillin. Kwaze kwaba ngo-1997 lapho i-chlorphenesin yatholakala khona ngamaFulentshi ngenxa yemiphumela yayo yokulwa namagciwane kanye ne-bacteriostatic futhi yafaka isicelo samalungelo obunikazi ahlobene.
1. Ingabe i-chlorphenesin iwumuthi wokuphumula imisipha?
Umbiko wokuhlola ukhombe ngokusobala ukuthi: isithako sezimonyo i-chlorphenesin asinawo umphumela wokukhulula imisipha. Futhi kukhulunywa ngaso kaningi embikweni: Nakuba isifinyezo sesiNgisi sesithako semithi i-chlorphenesin kanye nesithako sezimonyo i-chlorphenesin kokubili kuyi-Chlorphenesin, lokhu kokubili akufanele kudidaniswe.
2. Ingabe i-chlorphenesin iyacasula isikhumba?
Kungakhathaliseki ukuthi kungabantu noma ezilwaneni, i-chlorphenesin ayinakho ukucasuka kwesikhumba ekugxilweni okuvamile, futhi ayiyona into ezwela isikhumba noma i-photosensitizer. Kunezihloko ezine noma ezinhlanu kuphela mayelana nemibiko ye-chlorphenesin ebangela ukuvuvukala kwesikhumba. Futhi kunezimo ezimbalwa lapho i-chlorphenesin esetshenzisiwe ingu-0.5% kuya ku-1%, idlula kakhulu izinga elisetshenziswa ezimonyweni. Kwezinye izimo eziningana, kukhulunywe kuphela ukuthi i-chlorphenesin yayiqukethwe kule fomula, futhi kwakungekho bufakazi obuqondile bokuthi i-chlorphenesin ibangele i-dermatitis. Uma sibheka isisekelo esikhulu sokusetshenziswa kwe-chlorphenesin ezimonyweni, leli thuba alinakwa kangako.
3. Ingabe i-chlorphenesin izongena egazini?
Ukuhlolwa kwezilwane kubonise ukuthi enye i-chlorphenesin izongena egazini ngemva kokuthintana nesikhumba. Iningi le-chlorphenesin emuncwayo lizoguqulwa libe umchamo, futhi lonke lizokhishwa emzimbeni zingakapheli amahora angama-96. Kodwa yonke inqubo ngeke iveze noma yimiphi imiphumela emibi enobuthi.
4. Ingabe i-Chlorphenescine iyawunciphisa amasosha omzimba?
Ngeke. I-Chlorphenesin iyisivikelo somzimba esihlobene ne-antigen esiguqulwayo. Okokuqala, i-chlorphenesin idlala indima ebalulekile kuphela uma ihlanganiswa ne-antigen ekhethiwe, futhi ayinciphisi amasosha omzimba, futhi ayikhulisi izinga lokutheleleka kwezifo. Okwesibili, ngemva kokuyeka ukusebenzisa, umphumela wokucindezela amasosha omzimba we-antigen ekhethiwe uzonyamalala, futhi ngeke kube khona umphumela oqhubekayo.
5. Iyini isiphetho sokugcina sokuhlolwa kokuphepha?
Ngokusekelwe ezicelweni ezikhona kanye nokugxila kokusetshenziswa e-United States (ukuhlanza okungu-0.32%, uhlobo lwabahlali abangu-0.30%), i-FDA ikholelwa ukuthii-chlorphenesiniphephile njengesivikelo sobuhle.