I-Chlorphenesin

I-Chlorphenesin(104-29-0), igama lekhemikhali yi-3-(4-chlorophenoxy)propane-1,2-diol, ngokuvamile ihlanganiswa ukusabela kwe-p-chlorophenol nge-propylene oxide noma i-epichlorohydrin.Kuyi-agent ebanzi ye-antiseptic kanye ne-antibacterial ejenti, enomphumela we-antiseptic kuma-bacterium e-Gram-positive, amagciwane e-Gram-negative, i-yeasts kanye nesikhunta.Igunyaziwe ukuthi isetshenziswe emazweni amaningi nasezifundeni ezifana ne-Europe, United States, Japan, kanye ne-China.Umkhawulo wokusebenzisa ogunyazwe yimithetho eminingi kazwelonke kanye nemithethonqubo ngu-0.3%.
I-Chlorphenesinayizange isetshenziswe ekuqaleni njengesivikelo, kodwa njenge-immunosuppressant ehlobene ne-antigen evimbela ukukhululwa kwe-histamine ye-IgE-mediated embonini yezemithi.Kalula nje, i-anti-allergies.Kusukela ngo-1967, imboni yezokwelapha yayifunde ukusetshenziswa kwe-chlorphenesin ne-penicillin ukuvimbela ukungezwani komzimba okubangelwa i-penicillin.Kwaze kwafika ngo-1997 lapho i-chlorphenesin yatholwa amaFulentshi ngemiphumela yayo yokubulala amagciwane kanye ne-bacteriostatic futhi yafaka isicelo samalungelo obunikazi ahlobene.
1. Ingabe i-chlorphenesin ikhulula imisipha?
Umbiko wokuhlola uveze ngokucacile: isithako se-cosmetic chlorphenesin asinawo umphumela wokukhulula imisipha.Futhi kushiwo izikhathi eziningi embikweni: Nakuba isifinyezo sesiNgisi sesithako sezemithi i-chlorphenesin kanye nesithako sezimonyo i-chlorphenesin kokubili kuyi-Chlorphenesin, kokubili akufanele kudideke.
2. Ingabe i-chlorphenesin iyasicasula isikhumba?
Kungakhathaliseki ukuthi eyabantu noma izilwane, i-chlorphenesin ayinakho ukucasuka kwesikhumba lapho kugxilwe khona okuvamile, futhi akuyona into ezwela isikhumba noma i-photosensitizer.Kunezihloko ezine noma ezinhlanu kuphela mayelana nemibiko ye-chlorphenesin ebangela ukuvuvukala kwesikhumba.Futhi kunezimo ezimbalwa lapho i-chlorphenesin esetshenzisiwe ingu-0.5% kuya ku-1%, idlula kude inani elisetshenziswa ezimonyoni.Kwezinye izimo eziningana, kwashiwo kuphela ukuthi i-chlorphenesin yayiqukethwe kufomula, futhi kwakungekho bufakazi obuqondile bokuthi i-chlorphenesin yabangela i-dermatitis.Uma kucatshangelwa isisekelo esikhulu sokusetshenziswa kwe-chlorphenesin ezimonyoni, leli thuba alinakwa.
3. Ingabe i-chlorphenesin izongena egazini?
Ukuhlolwa kwezilwane kubonise ukuthi enye i-chlorphenesin izongena egazini ngemva kokuthintana nesikhumba.Iningi le-chlorphenesin emuncwayo izofakwa emchamweni, futhi yonke izokhishwa emzimbeni phakathi namahora angama-96.Kodwa yonke inqubo ngeke ikhiqize noma yimiphi imiphumela emibi enobuthi.
4. Ingabe i-Chlorphenescine izokwehlisa ukungatheleleki?
Ngeke.I-Chlorphenesin iyi-immunosuppressant ebuyela emuva ehlobene ne-antigen.Okokuqala, i-chlorphenesin idlala indima efanele kuphela lapho ihlanganiswa ne-antigen eqokiwe, futhi ayinciphisi ukuzivikela komzimba, futhi ayikhulisi izinga lokutheleleka kwezifo.Okwesibili, ngemva kokuqedwa kokusetshenziswa, umphumela we-immunosuppressive we-antigen ekhethiwe uzonyamalala, futhi ngeke kube nomphumela oqhubekayo.
5. Yisiphi isiphetho sokugcina sokuhlolwa kokuphepha?
Ngokusekelwe ezinhlelweni ezikhona kanye nokugxilisa ukusetshenziswa e-United States (i-wash-off 0.32%, uhlobo lomhlali ongu-0.30%), i-FDA ikholelwa ukuthii-chlorphenesiniphephile njengesilondolozi sezimonyo.