Ingabe i-phenoxyethanol iyingozi esikhumbeni?

Yiniphenoxyethanol?
I-Phenoxyethanol iyi-ether ye-glycol eyakhiwe ngokuhlanganisa amaqembu e-phenolic ne-ethanol, futhi ibonakala njengamafutha noma i-mucilage esimweni sayo samanzi.Kuyi-preservative evamile ezimonyoni, futhi ingatholakala kukho konke kusuka kumakhilimu obuso kuya ku-lotions.
I-Phenoxyethanol ifinyelela umphumela wayo wokulondoloza hhayi nge-antioxidant kodwa ngomsebenzi wayo wokulwa namagciwane, ovimbela futhi ukhiphe ngisho nemithamo emikhulu yama-microorganisms a-gram-positive kanye nama-negative.Iphinde ibe nomthelela omkhulu wokuvimbela ezinhlobonhlobo zamagciwane avamile afana ne-E. coli ne-Staphylococcus aureus.
Ingabe i-phenoxyethanol iyingozi esikhumbeni?
I-Phenoxyethanol ingaba yingozi uma idliwe ngemithamo emikhulu.Nokho, ukusetshenziswa kwezihlokophenoxyethanolekugxiliseni okungaphansi kuka-1.0% kusengaphakathi kwebanga eliphephile.
Sike saxoxa ngaphambilini ukuthi i-ethanol igaywa nge-acetaldehyde ngobuningi esikhumbeni nokuthi imuncwa ngobuningi esikhumbeni.Zombili lezi futhi zibaluleke kakhulu ku-phenoxyethanol.Esikhumbeni esinomgoqo oqinile, i-phenoxyethanol ingenye yama-glycol ethers ehlisa isithunzi ngokushesha kakhulu.Uma indlela ye-metabolic ye-phenoxyethanol ifana neye-ethanol, isinyathelo esilandelayo ukwakheka kwe-acetaldehyde engazinzile, kulandelwa i-phenoxyacetic acid kanye nokunye okungama-radicals mahhala.
Ungakhathazeki okwamanje!Lapho sixoxa nge-retinol ngaphambili, siphinde sakhuluma ngohlelo lwe-enzyme oluhlotshaniswa ne-metabolism ye-metabolismphenoxyethanol, nokuthi lezi zinqubo zokuguqula zenzeka ngaphansi kwe-stratum corneum.Ngakho-ke sidinga ukwazi ukuthi ingakanani i-phenoxyethanol empeleni imuncwa nge-transdermally.Kolunye ucwaningo olwahlola ukumuncwa kwe-sealant esekelwe emanzini equkethe i-phenoxyethanol nezinye izithako ezilwa namagciwane, isikhumba sengulube (esikwazi ukungena kalula kubantu) singamunca i-phenoxyethanol engu-2%, nayo ekhuphuke yaba ngu-1.4% kuphela ngemva kwamahora angu-6, kanye no-11.3% ngemuva kwamahora angama-28.
Lezi zifundo ziphakamisa ukuthi ukumuncwa nokuguqulwa kwephenoxyethanolekugxilweni okungaphansi kuka-1% alikho phezulu ngokwanele ukukhiqiza imithamo eyingozi yama-metabolites.Imiphumela efanayo iphinde yatholakala ocwaningweni olusebenzisa izinsana ezisanda kuzalwa ezingaphansi kwamaviki angama-27.Ucwaningo lwathi, "Aqueousphenoxyethanolayibangeli ukulimala kwesikhumba okuphawulekayo uma kuqhathaniswa nezilondolozi ezisekelwe ethanol.I-Phenoxyethanol ingena esikhunjeni sezinsana ezisanda kuzalwa, kodwa ayiwakhi umkhiqizo we-oxidation phenoxyacetic acid ngamanani abalulekile." Lo mphumela ubonisa nokuthi i-phenoxyethanol inezinga eliphakeme kakhulu le-metabolism esikhumbeni futhi ayidali monakalo omkhulu. liphathe, wesabani?
Ubani ongcono, i-phenoxyethanol noma utshwala?
Nakuba i-phenoxyethanol yenziwa i-metabolized ngokushesha kune-ethanol, ukugxila okuphezulu okukhawulelwe kokusetshenziswa kwezihloko kuphansi kakhulu ku-1%, ngakho akusona ukuqhathanisa okuhle.Njengoba i-stratum corneum ivimbela iningi lama-molecule ukuthi lingamunceki, ama-radicals mahhala akhiqizwa yilawa amabili mancane kakhulu kunalawo akhiqizwa ukusabela kwawo kwe-oxidation nsuku zonke!Ngaphezu kwalokho, ngenxa yokuthi i-phenoxyethanol iqukethe amaqembu e-phenolic ngendlela yamafutha, iyahwamuka futhi yome kancane kancane.
Isifinyezo
I-Phenoxyethanol iyisilondolozi esivamile esisetshenziselwa izimonyo.Iphephile futhi iyasebenza, futhi ingeyesibili kuma-parabens ngokuya ngokusetshenziswa.Nakuba ngicabanga ukuthi ama-parabens nawo aphephile, uma ufuna imikhiqizo ngaphandle kwama-parabens, i-phenoxyethanol iyisinqumo esihle!